AS-252424

• Catalog number
  B1611-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  AS-252424; AS 252424; AS252424; 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; PI3Kg/CKII Inhibitor
• Description
  AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50=230 nM. In a mouse model of peritonitis, PI 3-Kᵧ this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.
• CAS Number
  900515-16-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₄H₈FNO₄S
• Molecular Weight
  305.3
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A PI3Kg/CKII Inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD11045281
• PubChem CID
  16757575
• PubChem CID Link
• SMILES
  C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3
• InChi
  1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
• InChi Key
  OYYVWNDMOQPMGE-WUXMJOGZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AS-252424  
• Gene symbol
  KRT7-AS, DM1-AS, APOA1-AS, LRP1-AS, SIRT1-AS, ATXN2-AS, IRAIN, CTBP1-AS, HLA-B, EVX1-AS
• Short name
  AS-252424
• Alternative name
  AS-252424

Gene info

• Identity
  HGNC:52643
• Gene
  KRT7-AS
• Long gene name
  KRT7 antisense RNA 1
• Locus
  12q13.13
• Discovery year
  2016-11-18
• Entrez gene record
  109729127
• Pubmed identfication
  • 26876208
• RefSeq identity
  • NR_146274
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000169581

Gene info

• Identity
  HGNC:53125
• Gene
  DM1-AS
• Long gene name
  DM1 locus antisense RNA
• Locus
  19q13.32
• Discovery year
  2017-02-16
• Entrez gene record
  109729182
• Pubmed identfication
  • 28102759
• RefSeq identity
  • NR_147193
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:40079
• Gene
  APOA1-AS
• Long gene name
  APOA1 antisense RNA
• GenBank acession
  • DA327409
• Locus
  11q23.3
• Discovery year
  2014-01-04
• Entrez gene record
  104326055
• Pubmed identfication
  • 24388749
• RefSeq identity
  • NR_126362
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150649

Gene info

• Identity
  HGNC:51694
• Gene
  LRP1-AS
• Long gene name
  LRP1 antisense RNA
• Locus
  12q13.3
• Discovery year
  2015-05-07
• Entrez gene record
  105751187
• Pubmed identfication
  • 25937287
• RefSeq identity
  • NR_131938
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000171280

Gene info

• Identity
  HGNC:51912
• Gene
  SIRT1-AS
• Long gene name
  SIRT1 antisense RNA
• Locus
  10q21.3
• Discovery year
  2015-09-23
• Entrez gene record
  106633813
• Pubmed identfication
  • 26324025
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:51838
• Gene
  ATXN2-AS
• Long gene name
  ATXN2 antisense RNA
• Locus
  12q24.12
• Discovery year
  2016-05-12
• Entrez gene record
  102723619
• Pubmed identfication
  • 27531668
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000169599

Gene info

• Identity
  HGNC:50365
• Gene
  IRAIN
• Long gene name
  IGF1R antisense imprinted non-protein coding RNA
• Synonyms
  • IGF1R-AS
• Synonyms name
  • IGF1R antisense RNA
• Locus
  15q26.3
• Discovery year
  2014-08-07
• Entrez gene record
  104472848
• Pubmed identfication
  • 25092925
  • 27644252
• RefSeq identity
  • NR_126453
• Classification
  • Long non-coding RNAs with non-systematic symbols
• Locus Specific Databases
  • LRG_1064

Gene info

• Identity
  HGNC:48337
• Gene
  CTBP1-AS
• Long gene name
  CTBP1 antisense RNA
• Synonyms
  • PCAT10
• Synonyms name
  • prostate cancer associated transcript 10
• GenBank acession
  • AX747592
  • AK092548
• Locus
  4p16.3
• Discovery year
  2013-06-14
• Entrez gene record
  285463
• Pubmed identfication
  • 23644382
  • 25552498
• RefSeq identity
  • NR_104331
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000189534

Gene info

• Identity
  HGNC:4932
• Gene
  HLA-B
• Long gene name
  major histocompatibility complex, class I, B
• Synonyms gene
  • AS
• Synonyms gene name
  • ankylosing spondylitis
• GenBank acession
  • M15470
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  3106
• Pubmed identfication
  • 3459708
• RefSeq identity
  • NM_005514
• Classification
  • C1-set domain containing
  • Histocompatibility complex
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031153
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:40223
• Gene
  EVX1-AS
• Long gene name
  EVX1 antisense RNA
• Synonyms gene name
  • EVX1 antisense RNA (non-protein coding)
• Synonyms
  • EVX1-AS1
• Synonyms name
  • EVX1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • DB455833
  • DB260732
• Locus
  7p15.2
• Discovery year
  2012-05-03
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000159991

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