Aprepitant

• Catalog number
  9531-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  5-​[[(2R,​3S)-​2-​[(1R)-​1-​[3,​5-​bis(trifluoromethyl)phenyl]ethoxy]-​3-​(4-​fluorophenyl)-​4-​morpholinyl]methyl]-​1,​2-​dihydro-​3H-​1,​2,​4-​triazol-​3-​one; Emend; L-754,030; MK-869; ONO-7436
• Description
  Aprepitant is an anti-emetic compound that acts as a selective antagonist of human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC₅₀ = 0.09 nM for hNK1). Its prodrug is Fosaprepitant (Cat. No. 9529).
• CAS Number
  170729-80-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₁F₇N₄O₃
• Molecular Weight
  534.43
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective antagonist of human NK1 receptor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  6918365
• PubChem CID Link
• SMILES
  CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
• InChi
  InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
• InChi Key
  ATALOFNDEOCMKK-OITMNORJSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Aprepitant  
• Short name
  Aprepitant
• Alternative name
  Aprepitant

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