Antithrombin III Antibody

  • Catalog number
    7013-30T
  • Supplier
  • Price
    144.84 USD
  • Size
    30 µg
  • Antibody Target
    Antithrombin III
  • Target Alternative Name
    SERPINC1
  • Antibody Type
    Polyclonal
  • Species Reactivities
    Human, Mouse, Rat
  • Immunogen Sequence
    Human antithrombin III (Cat# 7298)
  • Accession
    P01008
  • Gene Id
    462
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Concentration
    0.5 mg/ml
  • Formulation
    30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
  • Purification
    Affinity purified rabbit IgG
  • Application
    Western blot
  • Positive Control
    Western blot: h serum, m muscle, rat kidney, recombinant protein
  • Application And Usages
    Western blot: 1-4 µg
  • Description
    SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability.
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    Verified
  • Immunocytochemistry Verified
    Not Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • ELISA Verified
    Not Verified
  • ChIP Verified
    Not Verified
  • Dot Blot Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    CPLX3, MGAT3, MGST3, P4HA3, CASP5, THAP4, IGHVIII-82, MT-CSB3, IGHVIII-67-4, IGHVIII-76-1
  • Short name
    Antithrombin III Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    rabbit IgG
  • Alternative name
    Antithrombin III (antibody to-)
  • Alternative technique
    antibodies
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
  • Synonyms gene name
    • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-27
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Mannosyl-glycoprotein N-acetylglucosaminyltransferases
  • VEGA ID
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    caspase 5
  • Synonyms gene name
    • caspase 5, apoptosis-related cysteine protease
    • caspase 5, apoptosis-related cysteine peptidase
  • Synonyms
  • Locus
  • Discovery year
    1996-09-13
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Caspases
    • Caspase recruitment domain containing
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable (III)-82 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable (III)-82
    • immunoglobulin heavy variable (III)-82 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    mitochondrially encoded conserved sequence block III
  • Synonyms gene
  • Synonyms gene name
    • conserved sequence block III
  • Synonyms
  • Locus
  • Discovery year
    1989-10-11
  • Pubmed identfication
  • Classification
    • Mitochondrially encoded regions
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable (III)-67-4 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable (III)-67-4
    • immunoglobulin heavy variable (III)-67-4 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable (III)-76-1 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable (III)-76-1
    • immunoglobulin heavy variable (III)-76-1 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products
Filters
+32-(0)1-658-90-45 [email protected]
Antithrombin III Antibody - Gentaur.com
Contact
Chat with gentaur.com employee