Anti-VWF (Caplacizumab), Humanized Antibody
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Catalog number
A2263-100
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Price
Please ask
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Size
100 µg
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Antibody Target
VWF
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Target Alternative Name
VWD, F8VWF, VWF, von Willebrand factor, Coagulation Factor VIII VWF
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
Human VWF
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Accession
DB06081
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Gene Id
7450
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In PBS, pH 7.5
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Purification
Protein A purified
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Description
The research-grade biosimilar is a humanized monoclonal antibody fragment that targets the von Willebrand factor (VWF). The original monoclonal antibody is a bivalent single-variable-domain linked by a three alanine linker. The antibody was approved for the treatment of acquired thrombotic thrombocytopenic purpura (TTP). Acquired TTP occurs due to the production of inhibitory autoantibodies against ADAMTS13. This leads to decreased ADAMTS13 activity that prevents cleavage of the von Willebrand factor. As a result, ultra-large von Willebrand factor multimers form that results in binding of the A1 domains of the VWF multimers to the platelets via glycoprotein Ibα and cause platelet aggregation. Aggregation of platelets leads to the formation of microthrombi, which causes ischemia of the tissues and dysfunction of multiple organs, ultimately leading to cognitive deficits, arterial hypertension, and early death. The original monoclonal antibody binds to the A1 domains of the VWF and inhibits the association with platelets thus preventing platelet aggregation and microthrombi formation
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
VWF, ADAMTS13
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Short name
Anti-VWF (Caplacizumab), Humanized Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
VH-VH
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Alternative name
Antibody toVWF (Caplacizumab), Humanized (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
von Willebrand factor, F8VWF and VWD, VWF and IDBG-13506 and ENSG00000110799 and 7450, chaperone binding, Extracellular, Vwf and IDBG-189967 and ENSMUSG00000001930 and 22371, VWF and IDBG-640531 and ENSBTAG00000012265 and 280958
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Gene info
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Identity
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Gene
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Long gene name
von Willebrand factor
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Synonyms gene
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Locus
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Discovery year
1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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