Anti-TNF-α (Certolizumab Pegol), Humanized Antibody
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Catalog number
A2142-100
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Price
538.81 USD
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Size
100 µg
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Antibody Target
TNF-α
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Target Alternative Name
CDP 870, CDP-870, CDP870, PHA-738144, CIMZIA, TNFSF2, TNF-alpha, TNFA, TNF-α, TNFα
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
Certolizumab pegol
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Accession
DB08904
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In PBS, pH 7.5
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Purification
Protein A purified
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Description
Certolizumab pegol (CZP) is a polyethylene glycol conjugated antigen-binding fragment of a humanized TNF-α monoclonal antibody. This antibody targets and neutralizes soluble and membrane forms of tumor necrosis factor alpha (TNF-α) and inhibits TNF-α mediated signaling in vitro. Unlike other TNF inhibitors, CZP does not contain the Fc region, which results in decreased Fc-mediated effects such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). CZP was developed by UCB Pharmaceuticals and received FDA approval for treatment of moderate to severe rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis, and psoriatic arthritis. CZP is marketed under the trade name Cimzia®
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Storage Condition
-80ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
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French translation
anticorps
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Gene target
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Gene symbol
TNF, TNFRSF1A, TNFRSF1B, LTBR
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Short name
Anti-TNF-α (Certolizumab Pegol), Humanized Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
Fab'-G1-kappa
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Alternative name
Antibody toTNF-α (Certolizumab Pegol), Humanized (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
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Gene info
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Identity
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Gene
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Long gene name
tumor necrosis factor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor (TNF superfamily, member 2)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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