Anti-SARS-CoV-2 Spike (NTD) Antibody (Clone# 4A8)

• Catalog number
  A2269-100
• Price
  536.04 USD
• Size
  100 µg

• Antibody Target
  SARS-CoV-2 Spike protein NTD
• Target Alternative Name
  Spike protein, COVID19, COVID 19, S protein, SARS-CoV S protein, S glycoprotein, E2, Peplomer protein, Spike protein S1, SARS Coronavirus, SARS-CoV-2, SARS CoV 2, 2019-nCoV, Spike protein S2, S2 protein, NTD, N-terminal domain, 4A8
• Antibody Type
  Monoclonal
• Clone
  4A8
• Species Reactivities
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV
• Immunogen Sequence
  Recombinant SARS-CoV-2 Spike protein NTD
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS, pH 7.5
• Application
  ELISA
• Application And Usages
  ELISA 1:5000 - 1:10,000
• Description
  The Spike protein (S) is a type I membrane fusion protein required for viral infection and pathogenesis. It is synthesized as a precursor protein between 1200 to 1300 amino acids. The mature protein is a heavily glycosylated trimer with 21-35 glycosylation sites. Upon cleavage by host proteases, it yields 2 subunits, S1 and S2. The S1 subunit consists of 672 amino acids and is divided into 4 domains: an N-terminal domain, a C-terminal domain (also called receptor binding domain, RBD), and 2 subdomains SD1 and SD2. The S2 subunit consists of 588 amino acids and is divided into 4 domains: an N-terminal hydrophobic fusion peptide (FP), 2 heptad repeats (HR1 and HR2), a transmembrane domain (TM), and a cytoplasmic tail. When S1 recognizes and binds to the host receptor, the S2 subunit undergoes a conformational change to bring about the fusion of viral envelope and host cell membrane. Current strategies involve the development of anti-viral drugs to inhibit infection of coronavirus.
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SARS-CoV-2   Spike   NTD   4A8  
• Gene symbol
  SARS1, SARS2
• Short name
  Anti-SARS-CoV-2 Spike (NTD) Antibody (Clone# 4A8)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG
• Alternative name
  Antibody toSARS-CoV-2 Spike (NTD) (antibody to-) (clonality# 4A8)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10537
• Gene
  SARS1
• Long gene name
  seryl-tRNA synthetase 1
• Synonyms gene
  • SARS
• Synonyms gene name
  • seryl-tRNA synthetase
• Synonyms
  • SERS
• Synonyms name
  • serine tRNA ligase 1, cytoplasmic
• GenBank acession
  • BC009390
• Locus
  1p13.3
• Discovery year
  1995-06-09
• Entrez gene record
  6301
• Pubmed identfication
  • 9431993
• RefSeq identity
  • NM_006513
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000011726

Gene info

• Identity
  HGNC:17697
• Gene
  SARS2
• Long gene name
  seryl-tRNA synthetase 2, mitochondrial
• Synonyms gene
  • SARSM
• Synonyms gene name
  • serine-tRNA ligase, mitochondrial
  • seryl-tRNA synthetase 2
• Synonyms
  • FLJ20450
  • mtSerRS
  • SerRSmt
  • SARS
  • SERS
  • SYS
• Synonyms name
  • serine tRNA ligase 2, mitochondrial
• GenBank acession
  • AB029948
• Locus
  19q13.2
• Discovery year
  2002-10-09
• Entrez gene record
  54938
• Pubmed identfication
  • 10764807
• RefSeq identity
  • NM_017827
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000182691

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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