Anti-PD-L1 (Avelumab), Human IgG1 Antibody

• Catalog number
  A2152-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  PD-L1
• Target Alternative Name
  MSB-0010718C, MSB0010682, B7-H, B7H1, B7-H1, CD274, PDCD1L1, PDL1, PD-L1, B7 homolog 1, PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human PD-L1
• Accession
  DB11945
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In PBS, pH 7.5
• Purification
  Protein A purified
• Description
  The research-grade biosimilar is a human IgG1 lambda monoclonal antibody that specifically targets programmed death-ligand 1 (PD-L1). Binding of PD-L1 to the PD-1 and B7.1 receptors occurs on T cells and antigen-presenting cells that results in suppression of cytotoxic T-cell activity, T-cell proliferation, and cytokine production. The antibody binds PD-L1 through the FG loops and blocks the interaction between PD-L1 and its receptors PD-1 and B7.1. This releases the suppression of immune responses and promotes the inhibition of tumor growth. Studies show that the drug is capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro. The original drug received FDA approval to treat Merkel cell cancer. It is currently been used in immunotherapy for several cancers
• Storage Condition
  -80ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• French translation
  anticorps

• Gene target
  PD-L1   Avelumab   IgG1  
• Gene symbol
  CD274, ENPP2, MTA2, MICALL1, IGKV1-16, ZBTB4, UCHL1, COLEC10, PDCD1, FAM71F1
• Short name
  Anti-PD-L1 (Avelumab), IgG1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  IgG1, lambda, IgG1
• Species
  Human, Humans
• Alternative name
  Antibody toPD-L1 (Avelumab), H. sapiens IgG1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

Gene info

• Identity
  HGNC:7411
• Gene
  MTA2
• Long gene name
  metastasis associated 1 family member 2
• Synonyms gene
  • MTA1L1
• Synonyms gene name
  • metastasis associated gene family, member 2
• Synonyms
  • MTA1-L1
• GenBank acession
  • AB016591
• Locus
  11q12.3
• Discovery year
  1999-05-17
• Entrez gene record
  9219
• Pubmed identfication
  • 9929979
• RefSeq identity
  • NM_004739
• Classification
  • GATA zinc finger domain containing
  • NuRD complex subunits
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000167684

Gene info

• Identity
  HGNC:29804
• Gene
  MICALL1
• Long gene name
  MICAL like 1
• Synonyms gene name
  • MICAL-like 1
• Synonyms
  • MIRAB13
  • KIAA1668
  • MICAL-L1
• Synonyms name
  • molecule interacting with Rab13
• GenBank acession
  • BK000466
• Locus
  22q13.1
• Discovery year
  2006-11-24
• Entrez gene record
  85377
• Pubmed identfication
  • 11258795
  • 12110185
• RefSeq identity
  • NM_033386
• Classification
  • LIM domain containing
• VEGA ID
  OTTHUMG00000150670

Gene info

• Identity
  HGNC:5732
• Gene
  IGKV1-16
• Long gene name
  immunoglobulin kappa variable 1-16
• Synonyms
  • IGKV116
  • L1
• GenBank acession
  • J00248
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28938
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151649

Gene info

• Identity
  HGNC:23847
• Gene
  ZBTB4
• Long gene name
  zinc finger and BTB domain containing 4
• Synonyms
  • KIAA1538
  • KAISO-L1
  • ZNF903
• GenBank acession
  • AB040971
• Locus
  17p13.1
• Discovery year
  2003-12-15
• Entrez gene record
  57659
• Pubmed identfication
  • 16354688
  • 25499219
• RefSeq identity
  • NM_020899
• Classification
  • BTB domain containing
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000108137

Gene info

• Identity
  HGNC:12513
• Gene
  UCHL1
• Long gene name
  ubiquitin C-terminal hydrolase L1
• Synonyms gene
  • PARK5
• Synonyms gene name
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
• Synonyms
  • PGP9.5
  • Uch-L1
• Synonyms name
  • ubiquitin thiolesterase
• GenBank acession
  • BC000332
• Locus
  4p13
• Discovery year
  1991-07-15
• Entrez gene record
  7345
• Pubmed identfication
  • 1840236
• RefSeq identity
  • NM_004181
• Classification
  • Ubiquitin C-terminal hydrolases
• VEGA ID
  OTTHUMG00000099377

Gene info

• Identity
  HGNC:2220
• Gene
  COLEC10
• Long gene name
  collectin subfamily member 10
• Synonyms gene name
  • collectin sub-family member 10 (C-type lectin)
• Synonyms
  • CL-L1
  • CL-10
• GenBank acession
  • AB002631
• Locus
  8q24.12
• Discovery year
  2000-04-11
• Entrez gene record
  10584
• Pubmed identfication
  • 10224141
• Classification
  • Collectins
  • C-type lectin domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000164971

Gene info

• Identity
  HGNC:8760
• Gene
  PDCD1
• Long gene name
  programmed cell death 1
• Synonyms gene
  • SLEB2
• Synonyms gene name
  • systemic lupus erythematosus susceptibility 2
• Synonyms
  • CD279
  • PD1
  • hSLE1
  • PD-1
• GenBank acession
  • AY206416
• Locus
  2q37.3
• Discovery year
  1994-05-24
• Entrez gene record
  5133
• Pubmed identfication
  • 7851902
  • 12402038
• RefSeq identity
  • NM_005018
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000151342

Gene info

• Identity
  HGNC:30704
• Gene
  FAM71F1
• Long gene name
  family with sequence similarity 71 member F1
• Synonyms gene
  • FAM137A
• Synonyms gene name
  • family with sequence similarity 137, member A
  • family with sequence similarity 71, member F1
• Synonyms
  • NYD-SP18
  • GARI-L1
• Synonyms name
  • Golgi-associated RAB2B interactor like 1
• GenBank acession
  • AF367470
• Locus
  7q32.1
• Discovery year
  2007-07-24
• Entrez gene record
  84691
• Pubmed identfication
  • 12477932
  • 34714330
• RefSeq identity
  • NM_032599
• VEGA ID
  OTTHUMG00000158276

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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