Anti-PD-L1 Antibody
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Catalog numberA1454-100
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Price:
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Size100 µg
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Antibody TargetPD-L1
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Target Alternative NamePD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
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Antibody TypePolyclonal
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Species ReactivitiesHuman
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Immunogen SequenceRecombinant human PD-L1
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AccessionQ9NZQ7
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Gene Id29126
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AppearanceColorless liquid
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FormLiquid
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FormulationIn PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
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PurificationAffinity purified
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ApplicationWB
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Positive ControlWB: PD-L1 human recombinant
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Application And UsagesWB: 1-4 µg
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DescriptionProgrammed death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans
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HandlingThe antibody solution should be gently mixed before use
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCD274, ENPP2, MTA2, MICALL1, IGKV1-16, ZBTB4, UCHL1, COLEC10, PDCD1, FAM71F1
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Short nameAnti-PD-L1 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibody toPD-L1 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameCD274 molecule
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Synonyms gene
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Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 2
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-08-10
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Entrez gene record
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Pubmed identfication
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemetastasis associated 1 family member 2
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Synonyms gene
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Synonyms gene name
- metastasis associated gene family, member 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-05-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- GATA zinc finger domain containing
- NuRD complex subunits
- Myb/SANT domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMICAL like 1
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Synonyms gene name
- MICAL-like 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-11-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- LIM domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 1-16
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namezinc finger and BTB domain containing 4
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BTB domain containing
- Zinc fingers C2H2-type
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameubiquitin C-terminal hydrolase L1
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Synonyms gene
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Synonyms gene name
- ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ubiquitin C-terminal hydrolases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecollectin subfamily member 10
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Synonyms gene name
- collectin sub-family member 10 (C-type lectin)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-11
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Entrez gene record
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Pubmed identfication
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Classification
- Collectins
- C-type lectin domain containing
- Complement system activation components
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogrammed cell death 1
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Synonyms gene
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Synonyms gene name
- systemic lupus erythematosus susceptibility 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-05-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefamily with sequence similarity 71 member F1
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Synonyms gene
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Synonyms gene name
- family with sequence similarity 137, member A
- family with sequence similarity 71, member F1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-07-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data