Anti-PD-1 Antibody

• Catalog number
  A1384-100
• Price
  335.3 USD
• Size
  100 µg

• Antibody Target
  PD-1
• Target Alternative Name
  PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human recombinant PD-1
• Accession
  Q15116
• Gene Id
  5133
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
• Purification
  Affinity purified
• Application
  Western blot
• Positive Control
  Western blot
• Application And Usages
  Western blot: 1-4 µg/ml
• Description
  Programmed death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PD-1  
• Gene symbol
  PDCD1, SNCA, ENPP2, SPATA2, ENPP3, PDCD1LG2, CD274, IGHVII-1-1, MIR1-1, TRUND-NNN8-1
• Short name
  Anti-PD-1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibody toPD-1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8760
• Gene
  PDCD1
• Long gene name
  programmed cell death 1
• Synonyms gene
  • SLEB2
• Synonyms gene name
  • systemic lupus erythematosus susceptibility 2
• Synonyms
  • CD279
  • PD1
  • hSLE1
  • PD-1
• GenBank acession
  • AY206416
• Locus
  2q37.3
• Discovery year
  1994-05-24
• Entrez gene record
  5133
• Pubmed identfication
  • 7851902
  • 12402038
• RefSeq identity
  • NM_005018
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000151342

Gene info

• Identity
  HGNC:11138
• Gene
  SNCA
• Long gene name
  synuclein alpha
• Synonyms gene
  • PARK1
  • PARK4
• Synonyms gene name
  • Parkinson disease (autosomal dominant, Lewy body) 4
  • synuclein, alpha (non A4 component of amyloid precursor)
• Synonyms
  • NACP
  • PD1
• Synonyms name
  • non A4 component of amyloid precursor
  • alpha-synuclein
  • α-synuclein
• GenBank acession
  • L08850
• Locus
  4q22.1
• Discovery year
  1995-01-24
• Entrez gene record
  6622
• Pubmed identfication
  • 8248242
  • 14593171
• VEGA ID
  OTTHUMG00000130948
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

Gene info

• Identity
  HGNC:14681
• Gene
  SPATA2
• Long gene name
  spermatogenesis associated 2
• Synonyms
  • KIAA0757
  • PD1
  • tamo
  • PPP1R145
• Synonyms name
  • protein phosphatase 1, regulatory subunit 145
• GenBank acession
  • AB018300
• Locus
  20q13.13
• Discovery year
  2001-03-15
• Entrez gene record
  9825
• RefSeq identity
  • NM_006038
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000032704

Gene info

• Identity
  HGNC:3358
• Gene
  ENPP3
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 3
• Synonyms gene
  • PDNP3
• Synonyms
  • PD-IBETA
  • gp130RB13-6
  • B10
  • CD203c
• GenBank acession
  • AF005632
• Locus
  6q23.2
• Discovery year
  1995-08-10
• Entrez gene record
  5169
• Pubmed identfication
  • 9344668
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
  • CD molecules
• VEGA ID
  OTTHUMG00000016292

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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