Anti-PCSK9 (Evolocumab), Human IgG2 Antibody
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Catalog number
A2168-100
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Price
Please ask
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Size
100 µg
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Antibody Target
PCSK9
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Target Alternative Name
AMG-145, AMG145, NN7415, FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC-1, HCHOLA3
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
Human PCSK9
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Accession
DB09303
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In PBS, pH 7.5
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Purification
Protein A purified
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Description
The research-grade biosimilar is a human IgG2 monoclonal antibody that is directed against proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a serine protease that binds to LDL receptors on the hepatocyte cell surface and promotes the lysosome-mediated degradation of these receptors. This results in decreased uptake and clearance of LDL-C (bad cholesterol) by the receptors. The monoclonal antibody binds to PCSK9 and prevents interaction with the LDL receptor. This promotes the recycling of the internalized LDL receptor to the hepatocyte cell surface and increased removal of LDL-C from the blood. The original drug received approval from the FDA to treat homozygous and heterozygous familial cholesterolemia. The drug has also been approved to treat patients with high cholesterol, whose LDL-C was not controlled by the statin treatment.
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Storage Condition
-80ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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French translation
anticorps
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Gene target
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Gene symbol
PCSK9
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Short name
Anti-PCSK9 (Evolocumab), IgG2 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG2, lambda
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Species
Human, Humans
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Alternative name
Antibody toPCSK9 (Evolocumab), H. sapiens IgG2 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
proprotein convertase subtilisin/kexin type 9, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, very-low-density lipoprotein particle receptor binding, Extracellular, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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