Anti-EGFR (Panitumumab), humanized antibody
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Catalog number
A1050-100
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Price
Please ask
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Size
100 µg
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Antibody Target
EGFR
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Target Alternative Name
Vectibix
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
EGFR
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Accession
AAI18666
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Gene Id
1956
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Appearance
Colourless liquid
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Form
Liquid
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Concentration
2 mg/ml
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Formulation
100 ug (2 mg/ml) of antibody in Phosphate buffered saline, pH 7.4.
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Purification
human IgG2k was expressed in a mouse cell line. IgG was purified from mouse cell culture supernatant by protein A chromatography.
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Application
Neutralization, ELISA
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Application And Usages
Neutralization : 1-20μg/ml; ELISA: 1μg/ml
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Description
Panitumumab is the human monoclonal antibody against epidermal growth factor receptor (EGFR). The EGFR is a member of a subfamily of type I receptor tyrosine kinases, including EGFR (HERl, c-ErbB-l), HER2/neu, HER3, and HER4. EGFR is a transmembrane glycoprotein that is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Overexpression of EGFR is also detected in many human cancers, including those of the colon and rectum. Panitumumab binds specifically and selectively to the EGFR, preventing binding of activating ligands, such as the EGF and transforming growth factor-α. This binding results in blockade of the essential downstream signaling pathways that are known to govern apoptosis, proliferation and differentiation of both normal and neoplastic cell types in a wide array of tissues.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans
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Handling
The antibody solution should be gently mixed before use
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Western Blot Verified
Not Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Dot Blot Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
EGFR-AS1, EGILA, EGFR, RHBDF1
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Short name
Anti-EGFR (Panitumumab), humanized antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
Human IgG1
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Alternative name
Antibody toEGFR (Panitumumab), humanized (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
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Gene info
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Identity
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Gene
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Long gene name
EGFR antisense RNA 1
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Locus
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Discovery year
2012-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
EGFR interacting lncRNA
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Synonyms
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Locus
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Discovery year
2019-09-27
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Pubmed identfication
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Classification
- Long non-coding RNAs with non-systematic symbols
Gene info
Gene info
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Identity
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Gene
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Long gene name
rhomboid 5 homolog 1
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Synonyms gene
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Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2003-04-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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