Anti-cGMP Antibody

• Catalog number
  A1285-50
• Price
  Please ask
• Size
  50 µg

• Antibody Target
  cGMP
• Target Alternative Name
  Cyclic GMP, Cyclic guanosine monophosphate
• Antibody Type
  Monoclonal
• Clone
  2F11E10
• Immunogen Sequence
  3', 5'-cyclic GMP-8-KLH
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  PBS, pH 7.4, containing 0.02% sodium azide
• Purification
  Affinity purified
• Application
  ELISA
• Positive Control
  ELISA
• Application And Usages
  ELISA: 0.04-0.1 µg/ml
• Description
  Guanosine 3, 5-cyclic monophosphate (cyclic GMP; cGMP) acts as a secondary messenger much like cyclic AMP. It is generally known to activate intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the cell surface. cGMP synthesis is catalyzed by guanylate cyclase (GC), which converts GTP to cGMP. Membrane-bound GC is activated by peptide hormones such as atrial natriuretic factor, while soluble GC is typically activated by nitric oxide (NO) to stimulate cGMP synthesis. cGMP is also a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. It also relaxes smooth muscle tissues. The roles of cGMP and cAMP may be linked, as evidenced by the fact that some cellular functions are controlled bi-directionally by both cAMP and cGMP. Some functions are stimulated by cGMP and suppressed by cAMP and vice versa.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  cGMP  
• Gene symbol
  PDE2A, PRKG2, PDE3A
• Short name
  Anti-cGMP Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse IgG2a, κ
• Alternative name
  Antibody tocGMP (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8777
• Gene
  PDE2A
• Long gene name
  phosphodiesterase 2A
• Synonyms gene name
  • phosphodiesterase 2A, cGMP-stimulated
• GenBank acession
  • U67733
• Locus
  11q13.4
• Discovery year
  1997-11-10
• Entrez gene record
  5138
• Pubmed identfication
  • 9210593
• RefSeq identity
  • NM_002599
• Classification
  • Phosphodiesterases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000102045

Gene info

• Identity
  HGNC:9416
• Gene
  PRKG2
• Long gene name
  protein kinase cGMP-dependent 2
• Synonyms gene name
  • protein kinase, cGMP-dependent, type II
• Synonyms
  • cGKII
  • PRKGR2
  • PKG2
• GenBank acession
  • X94612
• Locus
  4q21.21
• Discovery year
  1997-01-09
• Entrez gene record
  5593
• Pubmed identfication
  • 7498513
• RefSeq identity
  • NM_006259
• Classification
  • AGC family kinases
• VEGA ID
  OTTHUMG00000130296

Gene info

• Identity
  HGNC:8778
• Gene
  PDE3A
• Long gene name
  phosphodiesterase 3A
• Synonyms gene name
  • phosphodiesterase 3A, cGMP-inhibited
• Synonyms
  • CGI-PDE
• Synonyms name
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase A
• Locus
  12p12.2
• Discovery year
  1994-07-29
• Entrez gene record
  5139
• Pubmed identfication
  • 1315035
  • 10679291
• Classification
  • Phosphodiesterases
• VEGA ID
  OTTHUMG00000168962

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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