Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody

• Catalog number
  A2179-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CD22
• Target Alternative Name
  CMC 544, CMC-544, CMC544, PF-05208773, WAY-207294, Way 207294, SIGLEC2, SIGLEC-2
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human CD22
• Accession
  DB05889
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In PBS, pH 7.5
• Purification
  Protein A purified
• Description
  The research-grade biosimilar is an antibody-drug conjugate that is directed to CD22 which is highly expressed on the surface of B cells. The conjugate consists of Anti-CD22 humanized monoclonal antibody that is linked to a cytotoxic drug N-acetyl-gamma-calicheamicin via 4-(4 acetylphenoxy) butanoic acid (acetyl butyrate) linker. Upon internalization in the cell, the drug is detached from the antibody by hydrolytic cleavage. The drug binds to the minor groove of the DNA and forms a diradical species. This diradical species abstracts hydrogen ions from the phosphodiester bonds of DNA and causes double-strand DNA breaks, which leads to cell cycle arrest and apoptosis of the tumorigenic cells. The original antibody-drug conjugate is approved by the FDA to treat acute myeloid leukemia. It is also approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
• Storage Condition
  -80ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD22   Inotuzumab   Ozogamicin   Humanized  
• Gene symbol
  CD22
• Short name
  Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  IgG4, kappa
• Alternative name
  Antibody toCD22 (Inotuzumab Ozogamicin), Humanized (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  CD22 molecule, SIGLEC-2 and SIGLEC2, CD22 and IDBG-44001 and ENSG00000012124 and 933, protein binding, Cell surfaces, Cd22 and IDBG-171574 and ENSMUSG00000030577 and 12483, CD22 and IDBG-635610 and ENSBTAG00000011887 and 514582

Gene info

• Identity
  HGNC:1643
• Gene
  CD22
• Long gene name
  CD22 molecule
• Synonyms gene name
  • CD22 antigen
• Synonyms
  • SIGLEC-2
  • SIGLEC2
• Synonyms name
  • sialic acid binding Ig-like lectin 2
• GenBank acession
  • X52785
• Locus
  19q13.12
• Discovery year
  1991-06-06
• Entrez gene record
  933
• Pubmed identfication
  • 8496602
  • 1691828
• RefSeq identity
  • NM_001771
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • C2-set domain containing
  • Sialic acid binding Ig like lectins
• VEGA ID
  OTTHUMG00000183298

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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