Anti-CD19/CD3ε (Blinatumomab), Bispecific Antibody

• Catalog number
  A2225-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CD19/CD3ε
• Target Alternative Name
  AMG103, BITE MT-103, MEDI-538, MT103, bscCD19xCD3, MEDI 538, MEDI538, MT 103, B4, CVID3, CD19, T3E, TCRE, IMD18, CD3E
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human CD19/CD3ε
• Accession
  DB09052
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In PBS, pH 7.5
• Purification
  Protein A purified
• Description
  The research-grade biosimilar is a bispecific T-cell engager monoclonal antibody that targets both CD19 and CD3ε. A single molecule of this antibody possesses two binding sites: one for CD3ε expressed on T-cells and second for CD19 expressed on B-cells. The antibody forms a synapse between T-cells and malignant B-cells. Upon interaction, T-cells are activated, which release cytotoxic granules such as perforins and granzymes. Granzymes enter the cell cytoplasm with the help of perforins and initiate cell death pathways via activation of caspases. The original antibody has been approved by the FDA to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) in both adults and children
• Storage Condition
  -80ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD19/CD3ε   Blinatumomab   Bispecific  
• Gene symbol
  CD19
• Short name
  Anti-CD19/CD3ε (Blinatumomab), Bispecific Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  (scFv-kappa-heavy)-(scFv-heavy-kappa)
• Alternative name
  Antibody toCD19/CD3ε (Blinatumomab), Bispecific (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  CD19 molecule, B4 and CVID3, CD19 and IDBG-23791 and ENSG00000177455 and 930, protein binding, Cell surfaces, Cd19 and IDBG-209475 and ENSMUSG00000030724 and 12478, CD19 and IDBG-638894 and ENSBTAG00000032122 and

Gene info

• Identity
  HGNC:1633
• Gene
  CD19
• Long gene name
  CD19 molecule
• Synonyms gene name
  • CD19 antigen
• Locus
  16p11.2
• Discovery year
  1991-06-04
• Entrez gene record
  930
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
  • Minor histocompatibility antigens
• VEGA ID
  OTTHUMG00000097049
• Locus Specific Databases
  • CD19base: Mutation registry for CD19 deficiency
  • LRG_35

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products