Anti-CCR5 (Leronlimab), Humanized Antibody
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Catalog number
A2181-100
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Price
Please ask
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Size
100 µg
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Antibody Target
CCR5
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Target Alternative Name
PA14, PRO 140, PRO-140, PRO140, HuPRO-140, CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
Human CCR5
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Accession
DB05941
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In PBS, pH 7.5
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Purification
Protein A purified
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Description
The research-grade biosimilar is an investigational humanized IgG4 monoclonal antibody that specifically inhibits CCR5. CCR5 is a chemokine receptor that is expressed on the surface of a broad range of cells including T-cells, B-cells, and macrophages, and plays an important role in immune responses. Human Immunodeficiency Virus 1 (HIV-1) uses CCR5 as a co-receptor to enter and infect immunologic cells. The antibody binds to the hydrophilic extracellular domains of the CCR5 and competitively inhibits the CCR5-mediated HIV-1 entry into the host cells. The antibody does not target viruses using CXCR4 as a receptor to enter host cells. The original drug was granted Fast Track Designation by the US FDA to treat HIV infected patients in combination with HAART, and for metastatic triple-negative breast cancer. Currently, the drug is in early clinical trials to treat COVID-19 disease.
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Storage Condition
-80ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CCR5
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Short name
Anti-CCR5 (Leronlimab), Humanized Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG4, kappa
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Alternative name
Antibody toCCR5 (Leronlimab), Humanized (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
chemokine (C-C motif) receptor 5 (gene/pseudogene), CC-CKR-5 and CCCKR5 and CCR-5 and CD195 and CKR-5 and CKR5 and CMKBR5 and IDDM22, CCR5 and IDBG-30229 and ENSG00000160791 and 1234, chemokine (C-C motif) ligand 5 binding, Cell surfaces, CCR5 and IDBG-646247 and ENSBTAG00000008099 and 497017
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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