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Antibody Target
AURKB
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Target Alternative Name
AIK2, AIM-1, ARK-2, AurB, AURKB, Aurora-1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, Protein phosphatase 1 regulatory subunit 48 (PPP1R48), Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK1, STK12, STK5
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Antibody Type
Monoclonal
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Clone
AURKB/1521
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Species Reactivities
Human
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Immunogen Sequence
Recombinant human Aurora B protein fragment (aa 89-251)
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Accession
Q96GD4
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Gene Id
9212
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In 10 mM PBS with 0.05% BSA & 0.05% azide
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Purification
Protein A/G purification
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Application
FC, IF, WB
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Positive Control
WB: Recombinant Protein, Human Liver Lysate
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Application And Usages
FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1 ug/ml
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Description
Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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FACS Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Dot Blot Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
AURKB
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Short name
Anti-Aurora B Antibody (AURKB/1521)
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
Mouse IgG2b
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Alternative name
Antibody toAurora B (antibody to-) (aurora kinase B/1521)
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Alternative technique
antibodies
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Alternative to gene target
aurora kinase B, AIK2 and AIM-1 and AIM1 and ARK2 and AurB and aurkb-sv1 and aurkb-sv2 and IPL1 and PPP1R48 and STK12 and STK5, AURKB and IDBG-28278 and ENSG00000178999 and 9212, transferase activity, nuclei, Aurkb and IDBG-189620 and ENSMUSG00000020897 and 20877, AURKB and IDBG-635657 and ENSBTAG00000001717 and 360192
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