AKP-11

Alternative_name

2-Amino-2-[5-[5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl]propane-1,3-diol
Description

AKP-11 is a novel S1P1 (Sphingosine-1-phosphate receptor 1) agonist with potential therapeutic potential for treatment of MS and related autoimmune disorders.
CAS Number

1220973-37-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₂ClN₃O₅
Molecular Weight

443.88
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A novel S1P1 (Sphingosine-1-phosphate receptor 1) agonis
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46199832
PubChem CID Link
SMILES

CCCOC1=C(C=C(C=C1)C2=NC(=NO2)C3=CC4=C(C=C3)OC(=C4)C(CO)(CO)N)Cl
InChi

InChI=1S/C22H22ClN3O5/c1-2-7-29-18-6-4-14(9-16(18)23)21-25-20(26-31-21)13-3-5-17-15(8-13)10-19(30-17)22(24,11-27)12-28/h3-6,8-10,27-28H,2,7,11-12,24H2,1H3
InChi Key

YHNUTRJSCOJJKX-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

AKP-11
Gene symbol

PIRC52, PIRC51, IGKV1OR2-11, PIRC50, SNORD115-11, SNORD114-11, SNORD116-11, IGHV3OR16-11
Short name

AKP-11
Alternative name

AKP-11

Identity

HGNC:5768
Gene

IGKV1OR2-11
Long gene name

immunoglobulin kappa variable 1/OR2-11 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 1/OR2-11
- immunoglobulin kappa variable 1/OR2-11 pseudogene
Synonyms
- IGKV1/OR2-11
GenBank acession
- X51885
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28863
Pubmed identfication
- 2111145
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000184518

Identity

HGNC:5635
Gene

IGHV3OR16-11
Long gene name

immunoglobulin heavy variable 3/OR16-11 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable 3/OR16-11
- immunoglobulin heavy variable 3/OR16-11 pseudogene
Synonyms
- IGHV3/OR16-11
GenBank acession
- Z29608
Locus

16p11.2
Discovery year

2000-04-17
Entrez gene record

28305
Classification
- Immunoglobulin heavy (IGH) orphons
VEGA ID

OTTHUMG00000184731