Acidic Mammalian Chitinase Inhibitor Screening Kit (Fluorometric)

• Catalog number
  K693-100
• Price
  Please ask
• Size
  100 assays

• Summary
  • Detection method- Fluorescence (RFU= 320/445 nm) • Application-Screening/characterizing/studying Mammalian Chitinase inhibitors/activators
• Detection Method
  Fluorescence (RFU= 320/445 nm)
• Applications
  Screening/characterizing/studying Mammalian Chitinase inhibitors/activators
• Features Benefits
  • Simple and reliable test to screen AMCase inhibitors/activators • High-throughput compatible • Includes Inhibitor Control (Bisdionin F)
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Acidic Mammalian Chitinase (AMCase) belongs to the glycosyl hydrolase-18 family (EC 3.2.1.14), which is capable of hydrolyzing the β-(1, 4)-linkage between the adjacent N-acetyl glucosamine residues of chitin. AMCase is relatively abundant in the gastrointestinal tract and lung. It is highly expressed in the lungs of asthmatic patients and asthma animal models. In addition, the change in AMCase expression can be used to monitor Th-2/IL-13 mediated immune response and inflammation. Inhibition of AMCase activity has been considered as a therapeutic strategy to alleviate symptoms of allergic airway inflammation. Thus, there is a need to identify AMCase inhibitors as potential candidates to treat and/or prevent asthma. Biovision’s Acidic Mammalian Chitinase Inhibitor Screening Kit uses Bisdionin F— a highly selective AMCase inhibitor as positive control and it provides a simple, rapid, sensitive and reliable test suitable for screening/characterizing AMCase inhibitors.
• Data Sheet Link
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Acidic   Mammalian   Chitinase   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  Acidic Mammalian Chitinase Inhibitor Screening Kit (Fluorometric)
• Alternative name
  Acidic Mammalian Chitinase suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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