ACE1 Inhibitor Screening Kit (Colorimetric)
-
Catalog number
K719-100
-
Price
Please ask
-
Size
100 assays
-
-
Description
for high-throughput screening of ACE1 inhibitors
-
Summary
BioVision’s ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in OD at 345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the OD at 345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.
-
Detection Method
Absorbance, OD 345 nm
-
Species Reactivity
All
-
Applications
Screening/characterizing ACE1 inhibitors
-
Features Benefits
Reliable test for high-throughput screening of ACE1 inhibitors, Rapid, Simple
-
Storage Conditions
-20°C
-
Shipping Conditions
Gel Pack
-
Shelf life
12 months
-
Background
Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors. BioVision’s ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in OD at 345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the OD at 345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.
-
-
Properties
Colorimetric assays or detection use UV absorption or enzymatic color reaction.
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbol
ACE
-
Short name
ACE1 Inhibitor Screening Kit (Colorimetric)
-
Technique
colorimetric, colorimetry
-
Alternative name
ACE1 suppressor detection reagent (colorimetry)
-
Alternative technique
assays, kits
-
Alternative to gene target
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
-
Gene info
Product images
Similar products
