ABT-494

• Catalog number
  B1947-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide; Upadacitinib
• Description
  ABT-494 is a potent and selective Janus kinase JAK-1 inhibitor (IC₅₀ = 43 nM). ABT-494 is 74-fold more selective for JAK-1 over JAK-2 and 58-fold more selective for JAK-1 over JAK-3.
• CAS Number
  1310726-60-3 
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₉F₃N₆O
• Molecular Weight
  380.37
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective Janus kinase JAK-1 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  58557659
• PubChem CID Link
• SMILES
  CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F
• InChi
  InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
• InChi Key
  WYQFJHHDOKWSHR-MNOVXSKESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ABT-494  
• Gene symbol
  MIR494
• Short name
  ABT-494
• Alternative name
  ABT-494

Gene info

• Identity
  HGNC:32084
• Gene
  MIR494
• Long gene name
  microRNA 494
• Synonyms gene
  • MIRN494
• Synonyms
  • hsa-mir-494
• Locus
  14q32.31
• Discovery year
  2005-07-15
• Entrez gene record
  574452
• RefSeq identity
  • NR_030174
• Classification
  • MicroRNA MIR154 family

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