4SC-202

Alternative_name

E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide tosylic acid
Description

4SC-202 is an orally available potent HDAC inhibitor (HDACi) specific for class I HDAC isoenzymes with IC50s of 1.2/1.12/0.57 µM for HDAC1/2/3; displays high selectivity over ClassIIa/IIb/III HDACs. Displays antineoplastic activity.
CAS Number

1186222-89-8
Structure Available

Yes
Salt Form

Yes
Molecular Formula

C₃₀H₂₉N₅O₆S₂
Molecular Weight

619.71
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(> 50 mg/ml)
Handling

Protect from air and light
Tag Line

SC-202 is an orally bioavailable HDAC inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

44217246
PubChem CID Link
SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)C=CC(=O)NC4=CC=CC=C4N
InChi

InChI=1S/C23H21N5O3S.C7H8O3S/c1-27-16-19(14-25-27)18-7-9-20(10-8-18)32(30,31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-16H,24H2,1H3,(H,26,29);2-5H,1H3,(H,8,9,10)/b11-6+;
InChi Key

IAVXAZDVNICKFJ-ICSBZGNSSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:30033
Gene

PHPT1
Long gene name

phosphohistidine phosphatase 1
Synonyms
- PHP14
- HSPC141
- CGI-202
- DKFZp564M173
- bA216L13.10
Synonyms name
- phosphohistidine phosphatase 14kDa
- sex-regulated protein janus-a
GenBank acession
- AF131857
Locus

9q34.3
Discovery year

2004-03-23
Entrez gene record

29085
Pubmed identfication
- 11042152
- 8619474
RefSeq identity
- NM_014172
Classification
- Protein phosphatases
VEGA ID

OTTHUMG00000020950