3-Deazaneplanocin A
-
Catalog number2060-250
-
PricePlease ask
-
Size250 ug
-
-
Alternative_nameDZNep; NSC 617989; 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol
-
DescriptionA lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
-
CAS Number102052-95-9
-
Structure AvailableYes
-
Molecular FormulaC₁₂H₁₄N₄O₃
-
Molecular Weight262.26
-
Cell PermeableYes
-
Purity≥98%
-
SolubilitiesDMSO (20 mg/ml) or EtOH (1 mg/ml)
-
HandlingProtect from air and light
-
Tag LineA lysine methyltransferase EZH2 (KMT63) inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life24 months
-
MDL NumberMFCD12545899
-
PubChem CID73087
-
SMILESC1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
-
InChiInChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11 (8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
-
InChi KeyOMKHWTRUYNAGFG-IEBDPFPHSA-N
-
MSDS AvailableYes
-
Gene target
-
Short name3-Deazaneplanocin A
-
Alternative name3-Deazaneplanocin A
-