2-Hexyl-4-Pentynoic Acid

Alternative_name

2-prop-2-ynyloctanoic acid; 2-Propargyloctanoic Acid
Description

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.
CAS Number

96017-59-3
Structure Available

True
Salt Form

False
Molecular Formula

C₁₁H₁₈O₂
Molecular Weight

182.26
Cell Permeable

True
Purity

≥95%
Solubilities

~20 mg/ml in in DMSO, ~16 mg/ml in DMF in 0, ~33 mg/ml in in Ethanol, ~2mg/ml in PBS, pH 7.2 in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

An inhibitor of HDACs
Storage Condition

-20ºC
Shipping Condition

RT
Shelf Life

24months
MDL Number

MFCD00946863
PubChem CID

175664
PubChem CID Link
SMILES

CCCCCCC(CC#C)C(=O)O
InChi

InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)
InChi Key

DUQSBRQHALCSLC-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

False

Gene target

2-Hexyl-4-Pentynoic Acid
Gene symbol

MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4, MIR941-4, PIRC19, PIRC17
Short name

2-Hexyl-4-Pentynoic Acid
Alternative name

2-Hexyl-4-Pentynoic Acid

Identity

HGNC:5809
Gene

IGKV2OR2-4
Long gene name

immunoglobulin kappa variable 2/OR2-4 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
Synonyms
- IGKV2/OR2-4
GenBank acession
- X51883
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28858
Pubmed identfication
- 2111145
Classification
- Immunoglobulin kappa (IGK) orphons