Recombinant Aggrecan Interglobular Domain (ACAN-IGD) (Recombinant Protein)
#
-
Catalog number30 411 004
-
Price:
-
Size100 µg/ 200 µl
-
-
Protein typeRecombinant
-
Protein subtypeN/A
-
Protein familyAggrecan/versican proteoglycan family.
-
Protein descriptionThe Aggrecan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
-
Research area interestsDiseases associated with ACAN include Osteochondritis Dissecans, Short Stature, And Early-Onset Osteoarthritis and Spondyloepimetaphyseal Dysplasia, Aggrecan Type. Among its related pathways are Diseases associated with O-glycosylation of proteins and Integrin Pathway.
-
Package formliquid
-
Tested applicationssubstrate for aggrecanases and matrix metalloproteinases activity measurements
-
Other namesAggrecan Proteoglycan -IGD
-
Peptide sequenceT A E D F V D I P E N F F G V G G E E D I T V Q T V T W P D M E L P L P R N I T E G E A R G S V I L T V K P I F E V S P S P L E P E E P F T F A P E I G A T A F A E V E N E T G E A T R P W G F P T P G L G P A T A F T S E D L V V Q V T A V P G Q P H L P G G (His-tag)
-
Available target modificationNo
-
Expression systemE.coli
-
Product Subtypeprotein fragment
-
Active formNo
-
TagHis-tagged
-
Contents50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2
-
Protein purity>80%
-
Molecular weight21 kDa
-
UniProt numberP16112
-
Gene number176
-
AbbreviationACAN (partial)
-
Full nameaggrecan (partial)
-
Other desciptionThe recombinant protein contains cleavage sites for aggrecanases (E373 - A374 in human aggrecan) and matrix metalloproteinases (N341 - F342 in human aggrecan).
-
PurificationMentioned in the data sheet
-
PubMed citationsSee the data sheet
-
WarningsFor Research Use only.
-
Shipping conditionsdry ice
-
Storage conditionStore at -70°C
-
Technical datasheetContact us to receive the datasheet
-
PropertiesImmunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of mature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum, representing 0.25% of immunoglobulins in serum for virus detection. Anti-viral immunoglobulin D antibodies have a diagnostic value.
-
SourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolACAN
-
Short nameRecombinant Aggrecan Interglobular Domain (ACAN-IGD) (Recombinant Protein)
-
TechniqueRecombinant, IgD, IgDs, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
IsotypeIgD, IgD
-
SpeciesHomo sapiens
-
Alternative nameRec. Aggrecan Interglobular Domain (aggrecan-IGD) (Rec. Protein)
-
Alternative techniquerec, immunoglobulin-d
-
Alternative to gene targetaggrecan, AGC1 and AGCAN and CSPG1 and CSPGCP and MSK16 and SEDK, ACAN and IDBG-28773 and ENSG00000157766 and 176, carbohydrate binding, Extracellular, Acan and IDBG-193557 and ENSMUSG00000030607 and 11595, BT.92700 and IDBG-628953 and ENSBTAG00000016158 and 280985
-
Gene info
-
Identity
-
Gene
-
Long gene nameaggrecan
-
Synonyms gene
-
Synonyms gene name
- chondroitin sulfate proteoglycan 1
- aggrecan 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1992-06-17
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Sushi domain containing
- Hyalectan proteoglycans
- V-set domain containing
- C-type lectin domain containing
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data