Native Porcine Dipeptidylpeptidase IV (Native Protein)
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Catalog number
30 802 102
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Price
Please ask
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Size
100 mU/ 80 µl
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Protein type
Native
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Protein subtype
EC 3.4.14.5
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Protein family
Cysteinproteinase
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Protein description
Porcine DPPIV is a cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones (By similarity). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
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Research area interests
Diseases associated with DPP4 include Hepatosplenic T-Cell Lymphoma and Nasopharyngitis. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism.
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Package form
liquid
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Tested applications
Screening of inhibitors; Characterization of structure and function;
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Other names
DPPIV; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2)
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Peptide sequence
MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
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Available target modification
Yes
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Expression system
Porcine Kidney
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Product Subtype
full length
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Active form
Yes
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Tag
untagged
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Contents
20 mM Tris-HCl pH 8.0, 5 mM CaCl2, 1 μM ZnCl2, 0.05% NaN3
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Protein purity
>90%
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Molecular weight
120 kDa
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UniProt number
P22411
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Gene number
397492
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Abbreviation
DPP4
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Full name
dipeptidyl peptidase 4
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Other desciption
Native fully glycosylated Dipeptidypeptidase IV is purified from the porcine renal brush border of the proximal tubule.
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Purification
Mentioned in the data sheet
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PubMed citations
See the data sheet
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Warnings
For Research Use only.
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Shipping conditions
dry ice
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Storage condition
Store at -70°C
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Technical datasheet
Contact us to receive the datasheet
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Product images
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