alpha2-Macroglobulin (A2M) (Native Protein)

• Catalog number
  30 900 104
• Price
  Please ask
• Size
  1 mg lyophilized

• Protein type
  Native
• Protein subtype
  N/A
• Protein family
  Protease inhibitor and cytokine transporter
• Protein description
  A2M able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
• Research area interests
  Diseases associated with A2M include Alzheimer Disease and Alpha-2-Macroglobulin Deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade)
• Package form
  liquid
• Tested applications
  alpha2-Macroglobulin human is used to inhibit matrix metalloproteinases and serine proteases and to use to active site titration
• Other names
  C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5
• Peptide sequence
  MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
• Available target modification
  Yes
• Expression system
  Human Blood
• Product Subtype
  full length
• Active form
  Yes
• Tag
  untagged
• Contents
  50 mM phosphate buffer pH 7.4; 100mM NaCl, 500 µg glycine
• Protein purity
  >90% ; trace amount of IgM
• Molecular weight
  725 kDa
• UniProt number
  P01023
• Gene number
  2
• Abbreviation
  A2M
• Full name
  alpha-2-macroglobulin
• Other desciption
  Prepared from human blood.
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  cool packs or dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products

• Gene target
  alpha2-Macroglobulin   A2M   Native   Protein  
• Gene symbol
  A2M-AS1, A2M
• Short name
  alpha2-Macroglobulin (A2M) (Native Protein)
• Species
  Homo sapiens
• Alternative name
  alpha2-Macroglobulin (alpha-2-macroglobulin) (Native Protein)
• Alternative to gene target
  alpha-2-macroglobulin, A2MD and CPAMD5 and FWP007 and S863-7, A2M and IDBG-17623 and ENSG00000175899 and 2, calcium-dependent protein binding, Extracellular, A2m and IDBG-184734 and ENSMUSG00000030111 and 232345, A2M and IDBG-639675 and ENSBTAG00000018137 and 513856

Gene info

• Identity
  HGNC:27057
• Gene
  A2M-AS1
• Long gene name
  A2M antisense RNA 1
• Synonyms gene name
  • A2M antisense RNA 1 (non-protein coding)
  • A2M antisense RNA 1
• Locus
  12p13.31
• Discovery year
  2012-06-23
• Entrez gene record
  144571
• RefSeq identity
  • NR_026971
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168289

Gene info

• Identity
  HGNC:7
• Gene
  A2M
• Long gene name
  alpha-2-macroglobulin
• Synonyms
  • FWP007
  • S863-7
  • CPAMD5
• GenBank acession
  • BX647329
  • X68728
  • M11313
• Locus
  12p13.31
• Discovery year
  1986-01-01
• Entrez gene record
  2
• Pubmed identfication
  • 2408344
  • 9697696
• RefSeq identity
  • NM_000014
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
• VEGA ID
  OTTHUMG00000150267
• Locus Specific Databases
  • LRG_591

Similar products