ZWILCH Antibody

• Catalog number
  bs-9732R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ZWILCH Primary Polyclonal Antibody
• Also known as
  ZWILCH PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ZWILCH
• Specificity
  This is a highly specific antibody against ZWILCH.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ZWILCH
• Gene ID number
  55055
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  hZwilch; KNTC1AP; MGC111034; Protein zwilch homolog; ZWILC_HUMAN; zwilch;y ZWILCH protein; Zwilch, kinetochore associated, homolog.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ZWILCH  
• Gene symbol
  ZWILCH
• Short name
  Anti-ZWILCH
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ZWILCH Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  Zwilch, kinetochore associated, homolog (Drosophila), ZWILCH and IDBG-18211 and ENSG00000174442 and 55055, protein binding, Cytoplasm, Zwilch and IDBG-175909 and ENSMUSG00000032400 and 68014, ZWILCH and IDBG-645460 and ENSBTAG00000005213 and 534811

Gene info

• Identity
  HGNC:25468
• Gene
  ZWILCH
• Long gene name
  zwilch kinetochore protein
• Synonyms gene name
  • Zwilch, kinetochore associated, homolog (Drosophila)
• Synonyms
  • FLJ10036
  • KNTC1AP
• GenBank acession
  • AK023175
• Locus
  15q22.31
• Discovery year
  2005-07-25
• Entrez gene record
  55055
• Pubmed identfication
  • 12686595
• RefSeq identity
  • NM_017975
• Classification
  • RZZ complex
• VEGA ID
  OTTHUMG00000133194

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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