YY1 (1183CT6.5.23.6) Monoclonal Antibody

• Catalog number
  bsm-51412M
• Price
  Please ask
• Size
  0.1ml

• Long name
  YY1 (1183CT6.5.23.6) Monoclonal Antibody
• Also known as
  YY1 (1183CT6.5.23.6) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  YY1
• Specificity
  This is a highly specific antibody against YY1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  1183CT6.5.23.6
• Source
  Purified His-tagged YY1 protein was used to produced this monoclonal antibody.
• Gene ID number
  7528
• Swiss Prot
  P25490
• Tested Applications
  WB
• Recommended dilutions
  IHC(1:25)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1; Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; Yin and yang 1; YY-1; YY1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  YY1   1183CT6   Monoclonal  
• Gene symbol
  YY1
• Short name
  Anti-YY1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Alternative name
  YY1 (1183CT6.5.23.6) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12856
• Gene
  YY1
• Long gene name
  YY1 transcription factor
• Synonyms
  • NF-E1
  • DELTA
  • UCRBP
  • YIN-YANG-1
  • INO80S
• Synonyms name
  • INO80 complex subunit S
  • Yin and Yang 1 protein
• GenBank acession
  • BC020324
• Locus
  14q32.2
• Discovery year
  1993-09-17
• Entrez gene record
  7528
• Pubmed identfication
  • 1655281
  • 7912122
• RefSeq identity
  • NM_003403
• Classification
  • INO80 complex
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000150479

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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