Villin Antibody

• Catalog number
  bs-3810R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Villin Primary Polyclonal Antibody
• Also known as
  Villin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Villin
• Specificity
  This is a highly specific antibody against Villin.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  345-395/827
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Villin
• Gene ID number
  7429
• Swiss Prot
  P09327
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  VIL; D2S1471; Villin-1; VIL1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Villin  
• Gene symbol
  VILL, VIL1, EZR
• Short name
  Anti-Villin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Villin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:30906
• Gene
  VILL
• Long gene name
  villin like
• Locus
  3p22.2
• Discovery year
  2004-07-28
• Entrez gene record
  50853
• Pubmed identfication
  • 9179494
• RefSeq identity
  • NM_015873
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000130814

Gene info

• Identity
  HGNC:12690
• Gene
  VIL1
• Long gene name
  villin 1
• Synonyms gene
  • VIL
• Synonyms
  • D2S1471
• GenBank acession
  • X12901
• Locus
  2q35
• Discovery year
  2001-06-22
• Entrez gene record
  7429
• Pubmed identfication
  • 2846586
• RefSeq identity
  • NM_007127
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000133112

Gene info

• Identity
  HGNC:12691
• Gene
  EZR
• Long gene name
  ezrin
• Synonyms gene
  • VIL2
• Synonyms gene name
  • villin 2 (ezrin)
• Synonyms name
  • cytovillin 2
• GenBank acession
  • AF187552
• Locus
  6q25.3
• Discovery year
  1989-06-30
• Entrez gene record
  7430
• RefSeq identity
  • NM_003379
• Classification
  • FERM domain containing
  • A-kinase anchoring proteins
• VEGA ID
  OTTHUMG00000015917

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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