VEGFR3 (818CT12.1.1) Monoclonal Antibody

• Catalog number
  bsm-51245M
• Price
  Please ask
• Size
  0.1ml

• Long name
  VEGFR3 (818CT12.1.1) Monoclonal Antibody
• Also known as
  VEGFR3 (818CT12.1.1) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  VEGFR3
• Specificity
  This is a highly specific antibody against VEGFR3.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  818CT12.1.1
• Source
  Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
• Gene ID number
  2324
• Swiss Prot
  P35916
• Tested Applications
  WB, FCM, IHC-P
• Recommended dilutions
  FC(1:25), IHC-P(1:25)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3; Vascular endothelial growth factor receptor 3; Fms-like tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4; FLT4
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  VEGFR3   818CT12   Monoclonal  
• Gene symbol
  FLT4
• Short name
  Anti-VEGFR3
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Alternative name
  VEGFR3 (818CT12.1.1) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3767
• Gene
  FLT4
• Long gene name
  fms related receptor tyrosine kinase 4
• Synonyms gene name
  • fms-related tyrosine kinase 4
  • fms related tyrosine kinase 4
• Synonyms
  • VEGFR3
  • PCL
  • VEGFR-3
• Synonyms name
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • primary congenital lymphedema
• GenBank acession
  • X68203
• Locus
  5q35.3
• Discovery year
  1991-10-25
• Entrez gene record
  2324
• Pubmed identfication
  • 1319394
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000130931

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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