VCP Antibody
-
Catalog numberbs-1443R
-
PricePlease ask
-
Size0.1ml
-
-
Long nameVCP Primary Polyclonal Antibody
-
Also known asVCP PAb
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenVCP
-
SpecificityThis is a highly specific antibody against VCP.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityPolyclonal antibody
-
Clone numberPolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen range775-806/806
-
Subcellular locationCytoplasm, Nucleus
-
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VCP
-
Gene ID number7415
-
Swiss ProtP55072
-
Tested ApplicationsWB, IHC-P, IF(IHC-P)
-
Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivityHuman, Mouse, Rat
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenNecessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesp97; TERA; ALS14; IBMPFD; HEL-220; IBMPFD1; HEL-S-70; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit; Valosin-containing protein; VCP
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolVCPKMT, VCP
-
Short nameAnti-VCP
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
HostRabbit (Oryctolagus cuniculus)
-
IsotypeImmunoglobulin G (IgG)
-
Alternative nameVCP Polyclonal Antibody
-
Alternative techniqueantibodies
-
Alternative to gene targetvalosin containing protein, ALS14 and HEL-220 and HEL-S-70 and IBMPFD and IBMPFD1 and p97 and TERA, VCP and IDBG-61415 and ENSG00000165280 and 7415, ubiquitin-specific protease binding, nuclei, Vcp and IDBG-139755 and ENSMUSG00000028452 and 269523, BT.49331 and IDBG-632847 and ENSBTAG00000015000 and 507345
-
Gene info
-
Identity
-
Gene
-
Long gene namevalosin containing protein lysine methyltransferase
-
Synonyms gene
-
Synonyms gene name
- chromosome 14 open reading frame 138
- methyltransferase like 21D
- valosin containing protein lysine (K) methyltransferase
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-01-28
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- 7BS protein lysine methyltransferases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namevalosin containing protein
-
Synonyms gene name
- valosin-containing protein
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1996-08-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- AAA ATPases
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data