TrkA Antibody
-
Catalog numberbs-10210R
-
PricePlease ask
-
Size0.1ml
-
-
Long nameTrkA Primary Polyclonal Antibody
-
Also known asTrkA PAb
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenTrkA
-
SpecificityThis is a highly specific antibody against TrkA.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityPolyclonal antibody
-
Clone numberPolyclonal antibody
-
Concentration1ug per 1ul
-
Subcellular locationExtracellular
-
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TrkA
-
Gene ID number4914
-
Tested ApplicationsWB, FCM, IHC-P, IF(IHC-P)
-
Recommended dilutionsWB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivityHuman, Mouse, Rat
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenThe Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesCIPA; CIPA; DKFZp781I14186; gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; High affinity nerve growth factor receptor precursor; MTC; MTC; neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase receptor type 1; Ntrk 1; Ntrk1; Ntrk1; NTRK1_HUMAN; Oncogene TRK; Oncogene TRK; p140 TrkA; p140-TrkA; TRK 1; Trk A; TRK; TRK; Trk-A; TRK1; TRK1 transforming tyrosine kinase protein; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor A; Tyrosine kinase receptor; Tyrosine Receptor Kinase A.
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolNTRK1
-
Short nameAnti-TrkA
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
HostRabbit (Oryctolagus cuniculus)
-
IsotypeImmunoglobulin G (IgG)
-
Alternative nameTrkA Polyclonal Antibody
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nameneurotrophic receptor tyrosine kinase 1
-
Synonyms gene name
- neurotrophic tyrosine kinase, receptor, type 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1991-07-18
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Immunoglobulin like domain containing
- Receptor tyrosine kinases
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data