TLR6 Antibody

• Catalog number
  bs-2716R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TLR6 Primary Polyclonal Antibody
• Also known as
  TLR6 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TLR6
• Specificity
  This is a highly specific antibody against TLR6.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  340-380/796
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TLR6
• Gene ID number
  10333
• Swiss Prot
  Q9Y2C9
• Tested Applications
  WB, FCM, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CD286; Toll-like receptor 6; TLR6
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TLR6  
• Gene symbol
  TLR6
• Short name
  Anti-TLR6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TLR6 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  toll-like receptor 6, CD286, TLR6 and IDBG-13675 and ENSG00000174130 and 10333, lipopeptide binding, Plasma membranes, Tlr6 and IDBG-165921 and ENSMUSG00000051498 and 21899, BT.45021 and IDBG-641606 and ENSBTAG00000014031 and 407237

Gene info

• Identity
  HGNC:16711
• Gene
  TLR6
• Long gene name
  toll like receptor 6
• Synonyms gene name
  • toll-like receptor 6
• Synonyms
  • CD286
• Locus
  4p14
• Discovery year
  2001-10-01
• Entrez gene record
  10333
• Pubmed identfication
  • 10231569
• Classification
  • Toll like receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000128579

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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