TLR4 Antibody
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Catalog numberbs-1021R
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Price:
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Size0.1ml
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Long nameTLR4 Primary Polyclonal Antibody
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Also known asTLR4 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenTLR4
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SpecificityThis is a highly specific antibody against TLR4.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range780-830/835
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Subcellular locationCytoplasm
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SourceKLH conjugated synthetic peptide derived from rat TLR4
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Gene ID number21898
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Swiss ProtQ9QUK6
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Tested ApplicationsWB, FCM, IHC-P, IF(IHC-P), IF(ICC)
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Recommended dilutionsWB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
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Cross reactivityHuman, Mouse, Rat, Bovine
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenCooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesLps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTLR4
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Short nameAnti-TLR4
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameTLR4 Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targettoll-like receptor 4, ARMD10 and CD284 and TLR-4 and TOLL, TLR4 and IDBG-82738 and ENSG00000136869 and 7099, protein binding, Cell surfaces, Tlr4 and IDBG-156729 and ENSMUSG00000039005 and 21898, TLR4 and IDBG-638758 and ENSBTAG00000006240 and 281536
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Gene info
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Identity
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Gene
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Long gene nametoll like receptor 4
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Synonyms gene name
- toll-like receptor 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-06-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Toll like receptors
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data