TCF7L2 Antibody

• Catalog number
  bs-1280R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TCF7L2 Primary Polyclonal Antibody
• Also known as
  TCF7L2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TCF7L2
• Specificity
  This is a highly specific antibody against TCF7L2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  410-460/619
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TCF7L2
• Gene ID number
  6934
• Swiss Prot
  Q9NQB0
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  TCF4; TCF-4; Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; hTCF-4; TCF7L2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TCF7L2  
• Gene symbol
  TCF7L2
• Short name
  Anti-TCF7L2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TCF7L2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  transcription factor 7-like 2 (T-cell specific, HMG-box), TCF-4 and TCF4, TCF7L2 and IDBG-89861 and ENSG00000148737 and 6934, armadillo repeat domain binding, nuclei, Tcf7l2 and IDBG-177837 and ENSMUSG00000024985 and 21416, TCFL2 and IDBG-639856 and ENSBTAG00000021574 and 540481

Gene info

• Identity
  HGNC:11641
• Gene
  TCF7L2
• Long gene name
  transcription factor 7 like 2
• Synonyms gene
  • TCF4
• Synonyms gene name
  • transcription factor 7-like 2 (T-cell specific, HMG-box)
• Synonyms
  • TCF-4
• GenBank acession
  • X62871
• Locus
  10q25.2-q25.3
• Discovery year
  1998-01-20
• Entrez gene record
  6934
• Pubmed identfication
  • 1741298
• RefSeq identity
  • NM_030756
• Classification
  • TCF/LEF transcription factor family
  • Wnt enhanceosome complex
• VEGA ID
  OTTHUMG00000019070

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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