Survivin Antibody

• Catalog number
  bs-0726R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Survivin Primary Polyclonal Antibody
• Also known as
  Survivin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Survivin
• Specificity
  This is a highly specific antibody against Survivin.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  60-110/142
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Survivin
• Gene ID number
  332
• Swiss Prot
  O15392
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  API4; EPR-1; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; IAP4
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Survivin  
• Gene symbol
  BIRC5
• Short name
  Anti-Survivin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Survivin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:593
• Gene
  BIRC5
• Long gene name
  baculoviral IAP repeat containing 5
• Synonyms gene
  • API4
• Synonyms gene name
  • apoptosis inhibitor 4
  • baculoviral IAP repeat-containing 5
• Synonyms
  • EPR-1
  • survivin
• Synonyms name
  • survivin variant 3 alpha
• GenBank acession
  • U75285
• Locus
  17q25.3
• Discovery year
  1998-06-10
• Entrez gene record
  332
• Pubmed identfication
  • 8106347
  • 7947793
• RefSeq identity
  • NM_001168
• Classification
  • Baculoviral IAP repeat containing
  • Chromosomal passenger complex
• VEGA ID
  OTTHUMG00000177505

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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