SPG3A/Atlastin Antibody

• Catalog number
  bs-11759R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SPG3A/Atlastin Primary Polyclonal Antibody
• Also known as
  SPG3A/Atlastin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SPG3A/Atlastin
• Specificity
  This is a highly specific antibody against SPG3A/Atlastin.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SPG3A/Atlastin
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specic GTP binding protein; Brain-specic GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SPG3A/Atlastin  
• Gene symbol
  ATL1
• Short name
  Anti-SPG3A/Atlastin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SPG3A/Atlastin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11231
• Gene
  ATL1
• Long gene name
  atlastin GTPase 1
• Synonyms gene
  • SPG3
  • SPG3A
• Synonyms gene name
  • spastic paraplegia 3A (autosomal dominant)
• Synonyms
  • FSP1
  • AD-FSP
• Synonyms name
  • atlastin
• GenBank acession
  • AF131801
• Locus
  14q22.1
• Discovery year
  1993-10-28
• Entrez gene record
  51062
• Pubmed identfication
  • 8252041
  • 7825576
• Classification
  • Atlastins
• VEGA ID
  OTTHUMG00000140297
• Locus Specific Databases
  • LRG_360

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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