SNX1 Antibody

• Catalog number
  bs-2945R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SNX1 Primary Polyclonal Antibody
• Also known as
  SNX1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SNX1
• Specificity
  This is a highly specific antibody against SNX1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  420-470/522
• Subcellular location
  Membrane bound
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1.
• Gene ID number
  6642
• Swiss Prot
  Q13596
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  VPS5; HsT17379; Sorting nexin-1; SNX1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SNX1  
• Gene symbol
  SNX1
• Short name
  Anti-SNX1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SNX1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  sorting nexin 1, HsT17379 and VPS5, SNX1 and IDBG-16207 and ENSG00000028528 and 6642, phosphatidylinositol binding, Plasma membranes, Snx1 and IDBG-178734 and ENSMUSG00000032382 and 56440, SNX1 and IDBG-646500 and ENSBTAG00000002014 and 512029

Gene info

• Identity
  HGNC:11172
• Gene
  SNX1
• Long gene name
  sorting nexin 1
• Synonyms
  • SNX1A
  • MGC8664
  • HsT17379
  • Vps5
• GenBank acession
  • BC000357
• Locus
  15q22.31
• Discovery year
  1996-07-17
• Entrez gene record
  6642
• Pubmed identfication
  • 8638121
• RefSeq identity
  • NM_003099
• Classification
  • PX-BAR domain containing
  • Sorting nexins
• VEGA ID
  OTTHUMG00000172436

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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