Smac/Diablo Antibody

• Catalog number
  bs-50453R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Smac/Diablo Primary Polyclonal Antibody
• Also known as
  Smac/Diablo PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Smac/Diablo
• Specificity
  This is a highly specific antibody against Smac/Diablo.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Source
  Synthetic peptide
• Gene ID number
  56616
• Swiss Prot
  Q9NR28
• Tested Applications
  WB, IHC-P
• Recommended dilutions
  WB (1:1,000~2,000) IHC-P
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  SMAC; DFNA64; Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; DIABLO
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Smac/Diablo  
• Gene symbol
  DIABLO
• Short name
  Anti-Smac/Diablo
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Smac/Diablo Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  diablo, IAP-binding mitochondrial protein, DIABLO and IDBG-62263 and ENSG00000184047 and 56616, protein binding, Plasma membranes, Diablo and IDBG-199693 and ENSMUSG00000029433 and 66593, DIABLO and IDBG-632769 and ENSBTAG00000004199 and 493999

Gene info

• Identity
  HGNC:21528
• Gene
  DIABLO
• Long gene name
  diablo IAP-binding mitochondrial protein
• Synonyms gene name
  • diablo, IAP-binding mitochondrial protein
• Synonyms
  • SMAC
  • DIABLO-S
  • FLJ25049
  • FLJ10537
  • DFNA64
• Synonyms name
  • second mitochondria-derived activator of caspase
• GenBank acession
  • AF262240
• Locus
  12q24.31
• Discovery year
  2003-10-27
• Entrez gene record
  56616
• Pubmed identfication
  • 12749848
  • 17237824
  • 21722859
• RefSeq identity
  • NM_019887
• VEGA ID
  OTTHUMG00000157014

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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