RUVBL1 (507CT2.2.2) Monoclonal Antibody

• Catalog number
  bsm-51138M
• Price
  Please ask
• Size
  0.1ml

• Long name
  RUVBL1 (507CT2.2.2) Monoclonal Antibody
• Also known as
  RUVBL1 (507CT2.2.2) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RUVBL1
• Specificity
  This is a highly specific antibody against RUVBL1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  507CT2.2.2
• Source
  Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.
• Gene ID number
  8607
• Swiss Prot
  Q9Y265
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100~500)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  RVB1; TIH1; ECP54; TIP49; ECP-54; INO80H; NMP238; PONTIN; TIP49A; NMP 238; Pontin52; RuvB-like 1; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; INO80 complex subunit H; Nuclear matrix protein 238; Pontin 52; TIP60-associated protein 54-alpha; TAP54-alpha; RUVBL1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  RUVBL1   507CT2   Monoclonal  
• Gene symbol
  RUVBL1-AS1, RUVBL1
• Short name
  Anti-RUVBL1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1
• Alternative name
  RUVBL1 (507CT2.2.2) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40514
• Gene
  RUVBL1-AS1
• Long gene name
  RUVBL1 antisense RNA 1
• Synonyms gene name
  • RUVBL1 antisense RNA 1 (non-protein coding)
• Locus
  3q21.3
• Discovery year
  2011-07-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000159660

Gene info

• Identity
  HGNC:10474
• Gene
  RUVBL1
• Long gene name
  RuvB like AAA ATPase 1
• Synonyms gene name
  • RuvB (E coli homolog)-like 1
  • RuvB-like 1 (E. coli)
  • RuvB-like AAA ATPase
  • RuvB-like AAA ATPase 1
• Synonyms
  • TIP49
  • NMP238
  • RVB1
  • TIP49a
  • Pontin52
  • ECP54
  • TIH1
  • Rvb1
  • INO80H
• Synonyms name
  • pontin
  • INO80 complex subunit H
• GenBank acession
  • AF070735
• Locus
  3q21.3
• Discovery year
  1998-11-19
• Entrez gene record
  8607
• Pubmed identfication
  • 9774387
  • 9588198
• Classification
  • R2SP complex
  • AAA ATPases
  • R2TP complex
  • INO80 complex
  • SRCAP complex
  • DNA helicases
• VEGA ID
  OTTHUMG00000159658

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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