ROCK1 Antibody
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Catalog numberbs-50456R
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PricePlease ask
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Size0.1ml
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Long nameROCK1 Primary Polyclonal Antibody
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Also known asROCK1 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenROCK1
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SpecificityThis is a highly specific antibody against ROCK1.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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SourceSynthetic peptide
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Gene ID number6093
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Swiss ProtQ13464
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Tested ApplicationsWB
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Recommended dilutionsWB (1:2,000)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenProtein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesROCK-I; P160ROCK; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p160 ROCK-1; ROCK1
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolROCK1
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Short nameAnti-ROCK1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameROCK1 Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetRho-associated, coiled-coil containing protein kinase 1, P160ROCK and ROCK-I, ROCK1 and IDBG-1371 and ENSG00000067900 and 6093, transferase activity, Plasma membranes, Rock1 and IDBG-128359 and ENSMUSG00000024290 and 19877, ROCK1 and IDBG-644080 and ENSBTAG00000008403 and 785911
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Gene info
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Identity
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Gene
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Long gene nameRho associated coiled-coil containing protein kinase 1
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Synonyms
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Locus
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Discovery year1997-10-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- AGC family kinases
- Pleckstrin homology domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data