RIT1 Antibody

• Catalog number
  bs-8392R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RIT1 Primary Polyclonal Antibody
• Also known as
  RIT1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RIT1
• Specificity
  This is a highly specific antibody against RIT1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIT1
• Gene ID number
  6016
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  GTP binding protein Roc1; GTP-binding protein Rit1; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; RIT; RIT1; RIT1_HUMAN; ROC1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RIT1  
• Gene symbol
  RIT1
• Short name
  Anti-RIT1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RIT1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10023
• Gene
  RIT1
• Long gene name
  Ras like without CAAX 1
• Synonyms gene
  • RIT
• Synonyms gene name
  • Ric (Drosophila)-like, expressed in many tissues
• Synonyms
  • RIBB
  • ROC1
  • MGC125864
  • MGC125865
• Synonyms name
  • Ric-like, expressed in many tissues
  • GTP-binding protein Roc1
• GenBank acession
  • AF084462
• Locus
  1q22
• Discovery year
  1996-08-28
• Entrez gene record
  6016
• Pubmed identfication
  • 8824319
  • 8918462
• RefSeq identity
  • NM_006912
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000014104
• Locus Specific Databases
  • LRG_1372

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products