presenilin 1 Antibody
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Catalog numberbs-0024M
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PricePlease ask
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Size0.1ml
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Long namepresenilin 1 Primary Polyclonal Antibody
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Also known aspresenilin 1 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target Antigenpresenilin 1
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SpecificityThis is a highly specific antibody against presenilin 1.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range1-50/467
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Subcellular locationCytoplasm
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SourceKLH conjugated synthetic peptide derived from rat presenilin 1
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Gene ID number29192
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Swiss ProtP97887
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Rat, Rabbit
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesPresenilin-1; PS-1; Protein S182; Psen1; Psnl1
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPARL, PSEN1, HM13
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Short nameAnti-presenilin 1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostMouse (Mus musculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative namepresenilin 1 Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namepresenilin associated rhomboid like
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Synonyms gene
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Synonyms gene name
- presenilin associated, rhomboid-like
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-09-03
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Entrez gene record
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RefSeq identity
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Classification
- Rhomboid family
Gene info
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Identity
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Gene
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Long gene namepresenilin 1
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Synonyms gene
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Synonyms gene name
- Alzheimer disease 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Peptidase family A22
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namehistocompatibility minor 13
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-09-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Peptidase family A22
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data