PODXL (632CT5.11.4) Monoclonal Antibody
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Catalog number
bsm-51201M
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Price
Please ask
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Size
0.1ml
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Long name
PODXL (632CT5.11.4) Monoclonal Antibody
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Also known as
PODXL (632CT5.11.4) Monoclonal Antibody
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Category
Primary Antibodies
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Conjugation
Unconjugated
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Target Antigen
PODXL
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Specificity
This is a highly specific antibody against PODXL.
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Modification s
None
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Modification site s
Unmodified antibody
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Clonality
Monoclonal
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Clone number
632CT5.11.4
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Source
This PODXL antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human PODXL.
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Gene ID number
5420
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Swiss Prot
O00592
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Tested Applications
WB, IF
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Recommended dilutions
IF(1:100) , WB(1:500-5000),
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Cross reactivity
Human
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigen
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
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Purification method
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym names
PC; PCLP; Gp200; PCLP-1; Podocalyxin; GCTM-2 antigen; Podocalyxin-like protein 1; PODXL; PCLP1
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Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translation
anticorps
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Gene target
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Gene symbol
PODXL
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Short name
Anti-PODXL
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Technique
Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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Host
Mouse (Mus musculus)
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Isotype
Immunoglobulin G (IgG)1
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Alternative name
PODXL (632CT5.11.4) Monoclonal Antibody
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Alternative technique
antibodies
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Alternative to gene target
podocalyxin-like, Gp200 and PC and PCLP and PCLP-1, PODXL and IDBG-41798 and ENSG00000128567 and 5420, protein binding, Extracellular, Podxl and IDBG-133888 and ENSMUSG00000025608 and 27205, PODXL and IDBG-635552 and ENSBTAG00000010452 and 616366
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Gene info
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Identity
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Gene
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Long gene name
podocalyxin like
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Synonyms gene name
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Synonyms
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Locus
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Discovery year
1997-07-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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