PLK4 Antibody

• Catalog number
  bs-6393R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PLK4 Primary Polyclonal Antibody
• Also known as
  PLK4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PLK4
• Specificity
  This is a highly specific antibody against PLK4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PLK4/STK18
• Gene ID number
  10733
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PLK 4; PLK-4; PLK4; PLK4_HUMAN; Polo like Kinase 4; Polo-like kinase 4; Protein serine/threonine kinase; SAK; Serine/Threonine Kinase 18; Serine/threonine kinase; Serine/threonine protein kinase 18; Serine/threonine protein kinase PLK4; Serine/threonine protein kinase Sak; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase SAK; Snk Akin Kinase; STK 18; STK18.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PLK4  
• Gene symbol
  PLK4
• Short name
  Anti-PLK4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PLK4 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  polo-like kinase 4, SAK and STK18, PLK4 and IDBG-37545 and ENSG00000142731 and 10733, transferase activity, nuclei, Plk4 and IDBG-141445 and ENSMUSG00000025758 and 20873, PLK4 and IDBG-630057 and ENSBTAG00000039552 and 514405

Gene info

• Identity
  HGNC:11397
• Gene
  PLK4
• Long gene name
  polo like kinase 4
• Synonyms gene
  • STK18
• Synonyms gene name
  • serine/threonine kinase 18
  • polo-like kinase 4 (Drosophila)
  • polo-like kinase 4
• Synonyms
  • Sak
• GenBank acession
  • Y13115
• Locus
  4q28.1
• Discovery year
  1998-12-09
• Entrez gene record
  10733
• VEGA ID
  OTTHUMG00000133301

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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