-
Long name
PKA gamma Primary Polyclonal Antibody
-
Also known as
PKA gamma PAb
-
Category
Primary Antibodies
-
Conjugation
Unconjugated
-
Target Antigen
PKA gamma
-
Specificity
This is a highly specific antibody against PKA gamma.
-
Modification s
None
-
Modification site s
Unmodified antibody
-
Clonality
Polyclonal antibody
-
Clone number
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PKA gamma
-
Gene ID number
5568
-
Tested Applications
WB, IHC-P, IF(IHC-P)
-
Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigen
PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
-
Purification method
This antibody was purified via Protein A.
-
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym names
KAPG; PKA C gamma; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine threonine protein kinase; KAPCG_HUMAN.
-
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
