PCNA (Tyr211) Antibody

• Catalog number
  bs-2215R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PCNA (Tyr211) Primary Polyclonal Antibody
• Also known as
  PCNA (Tyr211) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PCNA Tyr211
• Specificity
  This is a highly specific antibody against PCNA Tyr211.
• Modification s
  Phosphorylation
• Modification site s
  Tyr211
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  190-230/261
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human PCNA around the phosphorylation site of Tyr211
• Gene ID number
  5111
• Swiss Prot
  P12004
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ATLD2; Proliferating cell nuclear antigen; PCNA; Cyclin
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PCNA   Tyr211  
• Gene symbol
  PCNA, PCNA-AS1
• Short name
  Anti-PCNA Tyr211
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PCNA (Tyr211) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8729
• Gene
  PCNA
• Long gene name
  proliferating cell nuclear antigen
• GenBank acession
  • J04718
• Locus
  20p12.3
• Discovery year
  1990-01-15
• Entrez gene record
  5111
• Pubmed identfication
  • 2565339
• VEGA ID
  OTTHUMG00000031798

Gene info

• Identity
  HGNC:37184
• Gene
  PCNA-AS1
• Long gene name
  PCNA antisense RNA 1
• Synonyms gene
  • PCNAAS
  • PCNA-AS
• Synonyms gene name
  • PCNA antisense RNA (non-protein coding)
  • PCNA antisense RNA 1 (non-protein coding)
• Locus
  20p12.3
• Discovery year
  2009-08-18
• Entrez gene record
  100302739
• Pubmed identfication
  • 10488129
  • 24704293
• RefSeq identity
  • NR_028370
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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