PANK2 Antibody

• Catalog number
  bs-8338R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PANK2 Primary Polyclonal Antibody
• Also known as
  PANK2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PANK2
• Specificity
  This is a highly specific antibody against PANK2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PANK2
• Gene ID number
  80025
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  C20orf48; HARP; hPANK2; HSS; MGC15053; NBIA1; PANK2; PANK2_HUMAN; Pantothenate kinase 2 Hallervorden Spatz syndrome; Pantothenate kinase 2; Pantothenic acid kinase 2; PKAN; RP23 387C21.4.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PANK2  
• Gene symbol
  PANK2-AS1, PANK2
• Short name
  Anti-PANK2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PANK2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40732
• Gene
  PANK2-AS1
• Long gene name
  PANK2 antisense RNA 1
• Locus
  20p13
• Discovery year
  2019-09-19
• Entrez gene record
  107985395
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:15894
• Gene
  PANK2
• Long gene name
  pantothenate kinase 2
• Synonyms gene
  • C20orf48
  • NBIA1
• Synonyms gene name
  • neurodegeneration with brain iron accumulation 1 (Hallervorden-Spatz syndrome)
• Synonyms
  • HSS
  • FLJ11729
  • PKAN
  • HARP
• Synonyms name
  • Hallervorden-Spatz syndrome
  • pantothenate kinase-associated neurodegeneration
• GenBank acession
  • AK021791
• Locus
  20p13
• Discovery year
  2001-06-21
• Entrez gene record
  80025
• Pubmed identfication
  • 8944032
  • 11479594
• RefSeq identity
  • NM_024960
• Classification
  • Pantothenate kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031768
• Locus Specific Databases
  • LRG_1016

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products