PAK1/2/3(Thr423) Antibody

• Catalog number
  bs-1652R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PAK1/2/3(Thr423) Primary Polyclonal Antibody
• Also known as
  PAK1/2/3(Thr423) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PAK1/2/3 Thr423
• Specificity
  This is a highly specific antibody against PAK1/2/3 Thr423.
• Modification s
  Phosphorylation
• Modification site s
  Thr423
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of (Thr423)
• Gene ID number
  5058
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PAK1 + PAK2 + PAK3 phospho T423; Alpha PAK; Beta PAK; Gamma PAK; Oligophrenin 3; OPHN3; p21 activated kinase 1; p21 Activated Kinase 1 + 2 + 3; p21 activated kinase 2 ; p21 activated kinase 3; P65 PAK; PAK1; PAK2; PAK3; PAK3beta; PAK65; PAKalpha; PAKgamma; S6/H4 kinase; Serine/threonine protein kinase PAK 1; Serine/threonine protein kinase PAK 2; Serine/threonine protein kinase PAK 3; Serine/threonine protein kinase PAK1; Serine/threonine protein kinase PAK2; Serine/threonine protein kinase PAK3; PAK1_HUMAN; PAK2_HUMAN; PAK3_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PAK1/2/3   Thr423  
• Gene symbol
  PAK1, PKN1
• Short name
  Anti-PAK1/2/3 Thr423
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PAK1/2/3(Thr423) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  p21 protein (Cdc42/Rac)-activated kinase 1, PAKalpha, PAK1 and IDBG-65610 and ENSG00000149269 and 5058, transferase activity, nuclei, Pak1 and IDBG-199974 and ENSMUSG00000030774 and 18479, PAK1 and IDBG-642220 and ENSBTAG00000010191 and 533729

Gene info

• Identity
  HGNC:8590
• Gene
  PAK1
• Long gene name
  p21 (RAC1) activated kinase 1
• Synonyms gene name
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • p21 protein (Cdc42/Rac)-activated kinase 1
• Synonyms name
  • STE20 homolog, yeast
• GenBank acession
  • U51120
• Locus
  11q13.5-q14.1
• Discovery year
  1997-12-05
• Entrez gene record
  5058
• Pubmed identfication
  • 8805275
  • 9533029
• RefSeq identity
  • NM_002576
• VEGA ID
  OTTHUMG00000165138

Gene info

• Identity
  HGNC:9405
• Gene
  PKN1
• Long gene name
  protein kinase N1
• Synonyms gene
  • PRKCL1
• Synonyms gene name
  • protein kinase C-like 1
• Synonyms
  • DBK
  • PRK1
  • PKN
  • MGC46204
  • PAK1
• GenBank acession
  • S75546
• Locus
  19p13.12
• Discovery year
  1997-10-10
• Entrez gene record
  5585
• Pubmed identfication
  • 9570957
• RefSeq identity
  • NM_002741
  • NM_213560
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
• VEGA ID
  OTTHUMG00000039611

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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