NTRK1 (185CT47.6.1) Monoclonal Antibody

• Catalog number
  bsm-51044M
• Price
  Please ask
• Size
  0.1ml

• Long name
  NTRK1 (185CT47.6.1) Monoclonal Antibody
• Also known as
  NTRK1 (185CT47.6.1) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  NTRK1
• Specificity
  This is a highly specific antibody against NTRK1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  185CT47.6.1
• Source
  This NTRK1 Monoclonal antibody was raised using purified His-tagged recombinant human NTRK1.
• Gene ID number
  4914
• Swiss Prot
  P04629
• Tested Applications
  WB
• Recommended dilutions
  WB(1:500~4000)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
• Purification method
  Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; gp140trk; NTRK1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  NTRK1   185CT47   Monoclonal  
• Gene symbol
  NTRK1
• Short name
  Anti-NTRK1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1 κ
• Alternative name
  NTRK1 (185CT47.6.1) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  neurotrophic tyrosine kinase, receptor, type 1, MTC and p140-TrkA and TRK and Trk-A and TRK1 and TRKA, NTRK1 and IDBG-103632 and ENSG00000198400 and 4914, transferase activity, Cell surfaces, Ntrk1 and IDBG-158646 and ENSMUSG00000028072 and 18211, BT.22873 and IDBG-631386 and ENSBTAG00000003060 and 353111

Gene info

• Identity
  HGNC:8031
• Gene
  NTRK1
• Long gene name
  neurotrophic receptor tyrosine kinase 1
• Synonyms gene name
  • neurotrophic tyrosine kinase, receptor, type 1
• Synonyms
  • TRK
  • TRKA
  • MTC
• Synonyms name
  • high affinity nerve growth factor receptor
• GenBank acession
  • Y09028
• Locus
  1q23.1
• Discovery year
  1991-07-18
• Entrez gene record
  4914
• Pubmed identfication
  • 2869410
• RefSeq identity
  • NM_002529
• Classification
  • Immunoglobulin like domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000041304
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_261

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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